LARGE HIATUS HERNIA: TIME FOR A PARADIGM SHIFT?

Large hiatus hernia: time for a paradigm shift?

Abstract Background Laparoscopic large hiatal hernia (LHH) repair remains a challenge despite three decades of ongoing attempts at improving surgical outcome.Its rarity and complexity, coupled with suboptimal initial approach that is usually best suited for small symptomatic herniae have contributed to unacceptable higher failure rates.Results We h

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Drosophila Yemanuclein and HIRA cooperate for de novo assembly of H3.3-containing nucleosomes in the male pronucleus.

The differentiation of post-meiotic spermatids in animals is characterized by a unique reorganization of their nuclear architecture and chromatin composition.In many species, the formation of sperm nuclei involves the massive replacement Accessories - Socks of nucleosomes with protamines, followed by a phase of extreme nuclear compaction.At fertili

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